The Caldwell Redskins (3-4), who snapped a four- game losing streak last week with a victory over Frontier, will travel to Beverly Friday night to take on the Fort Frye Cadets (5-2) in a Pioneer Valley conference matchup.
A win by the Cadets would certainly increase their chance at a potential playoff berth, while the Skins will need to run the table and get a lot of help from some other teams to have any chance at the post season.
Fort Frye has won five of their last six games, including last week's 27-15 victory over Buckeye Trail.
Cadet running back Spencer Lang rushed for 155 yards on 16 carries and a touchdown while his brother Chandler rushed for a pair of touchdowns and completed eight-of-14 passes for 88 yards and another score in the win against Trail.
The Cadets' last defeat came in Week 5, a 32-0 loss to the always-tough Monroe Central Seminoles.
The Cadet defense is yielding just 18.6 points per game on the season, while the Fort Frye offense has been shutout in each of its two losses on the year.
The Redskins piled up 432 total yards in the 60-6 win over Frontier with running back Adam Rossiter leading the way with 159 yards rushing and four touchdowns.
Quarterback Jensen Croucher completed seven-of 10 passes for 118 yards and three touchdowns.
Caldwell, despite the losing record for the season is averaging 33.7 points on offense while allowing only 23.7 points per game.
Last year the Skins dominated Fort Frye, 34-7 in Caldwell.
MONROE CENTRAL (6-1) at BARNESVILLE (7-0)
In what on paper looks to be an outstanding matchup, the undefeated Barnesville Shamrocks will host the Monroe Central Seminoles.
The Seminoles dropped their first game of the season to Columbiana, before reeling off six consecutive victories, including last week's 21-7 win over Shenandoah.
Barnesville is coming off a 27-7 win last week over Steubenville Catholic Central and are outscoring its opponents on the season by a score of 214-79.
In the past three games the tough Shamrock defense has allowed just 19 total points in victories over Catholic Central, Shenandoah and Caldwell.
In last week's win over the Zeps, Monroe Central senior quarterback Tyler Kinchen rushed for 157 yards on 24 carries and a touchdown and threw for 52 more yards, including a 20-yard touchdown strike to Korey Lafferre.
Kinchen has rushed for 666 yards and 10 touchdowns on the season, while passing for 635 yards and eight scores.
The Seminoles themselves feature a very tough defense and are allowing just over 10 points per game on the season.
Last week against Shenandoah, the Noles' defense limited running back Shane Crum to only 21 rushing yards, and junior Josh Guiler came up with three quarterback sacks.
Last year, Monroe Central defeated Barnesville 21-7 in Woodsfield.
WATERFORD (4-3) at SOUTHERN (2-5)
Head coach Chad Ross and his Waterford Wildcats will travel to Racine to battle the Southern Tornadoes Friday in search of their second consecutive victory in a TVC contest.
Last week the Wildcats came up with a hard fought 13-7 victory over Franklin Furnace Green to get their record back over the .500 mark.
The Cats jumped out to an early 13-0 lead and held off a late Green rally to notch their third conference victory against a pair of losses.
Waterford freshmen running back Darek Brown made his presence known against Green, rushing for 143 yards on 19 carries and a touchdown to spark the Cats.
Brian Moore contributed 72 yards rushing to the Wildcat attack, while also chipping in 52 yards receiving on five catches.
Quarterback Trevor Lang completed just six-of-14 passes against Green for 57 yards.
Southern snapped a three- game losing streak last week with a 20-12 victory over Miller.
Waterford has struggled to score points this season, averaging under 13 points per contest.
The Cats have victories on the season against the likes of Miller, Federal Hocking, and Eastern in addition to Green, while Southern's other win on the season came at the hands of Belpre.
Last year in Waterford the Wildcats downed the Tornadoes 35-6.
FRONTIER (0-7) at VALLEY (2-5)
In what might be the best opportunity left on the schedule for the Frontier Cougars to break into the win column, the Cougars travel across the river to take on Valley Wetzel.
Two weeks ago against Fort Frye, the Cougars came up just a little short, dropping a heartbreaking 21-20 nail-biter to the Cadets.
Last week the Cougars were demolished by the Caldwell Redskins, 60-6, in Caldwell.
Quarterback Jordan Jefferson went down with a leg injury against the Redskins and Frontier head coach Todd Bradford was forced to go with the untested quarterback combo of Eddie Salazar and Seth Foutty.
Sophomore running back Jared Howell was one of the few bright spots for the Cougars last week as he rushed for 68 yards on six fourth-quarter carries and scored the lone Cougar touchdown.
Valley has victories on the season against Hundred, in Week 3, and posted its second win of the season last week, defeating St. John Central 39-21.
Both schools have struggled to put points on the board this season as Valley has been held to 14 points or less in four of its seven games, and the Cougars have been held to 14 or fewer in six of their seven games.
Last year, offense was not a problem for the Cougars, as they defeated Valley 49-20 in New Matamoras.
RIVER (3-4) at SHENANDOAH (3-4)
A pair of Pioneer Valley conference schools will look to get back to the .500 mark, when the Shenandoah Zeps host the River Pilots Friday night in Sarahsville.
River comes into the game fresh off of a 7-6 win over Bridgeport one week ago, while Shenandoah dropped a 21-7 decision to the Monroe Central Seminoles.
The Zeps have lost three of their last four games, and have struggled to find any kind of consistency in the 2011 season.
River's offense has came to life the past several weeks after being shut out for more than 12 consecutive quarters early in the season.
Shenandoah will more than likely rely once again on the running of senior tailback Shane Crum.
Crum gained just 21 yards rushing last week against Monroe Central, but did manage 102 receiving yards .
In addition to Bridgeport, River has a shutout victory against Fort Frye and an overtime win over Caldwell to its credit.
Shenandoah's three victories have come at the hands of Frontier, Meadowbrook and Buckeye Trail.
Last year Shenandoah traveled to Hannibal and returned with a 37-13 victory over River.
TRIMBLE (4-2) at BELPRE (0-7)
The Belpre Golden Eagles will once again try for that first win of the 2011 season as they host a red-hot Trimble Tomcat team in Belpre Friday night.
Trimble came out of the gate slowly, dropping its first two games, before going on a four-game win streak, including last week's 49-0 domination of Eastern.
Key offensive players for Trimble figure to be quarterback Justin Jewell, running back Austin Keith and receiver Wyatt Deak.
The Eagles have struggled the past two years, dropping 16 of their last 17 games and are coming off of a 62-7 drubbing by South Gallia.
Belpre's offense has mustered just 37 points on the season (5.2 points per game), while the Golden Eagle defense is allowing just under 35 points per contest.
Eagle head coach Greg Adams decided to go with freshman Manny Tulius at quarterback last week against South Gallia.
Running back Nate Teeters proved to be the bright spot, rushing for 121 yards on 19 carries, while Cody Martin added 56 yards on just five carries.
Last year Trimble defeated the Golden Eagles 60-7 in Glouster.
WEST MUSKINGUM (0-7) at MORGAN (1-6)
A pair of schools hungry for a victory will do battle in McConnelsville Friday night when the West Muskingum Tornadoes visit the Morgan Raiders.
The Tornadoes are still searching for their first win of the season, while the Raiders defeated Union Local 20-9 in Week 2 for their lone win.
The Raiders should be able to get the ball in the end zone against a West Muskingum team that has allowed an average of seven touchdowns per game on the season.
Last week the Raiders dropped a 28-13 game to John Glenn.
The Raiders are paced on offense by quarterback Clinton Campbell, who leads the team in rushing with 361 yards and four touchdowns and Jordan Greer who has 324 yards and three scores on the season.
Bryk Hardesty and Dirk Ponchak lead the Morgan defense in tackles.
Last year Morgan edged the Tornadoes 13-7 in Zanesville.
GILMER COUNTY (1-5) AT ST.MARYS (2-4)
The St. Marys Blue Devils will be looking to put together their first winning streak of the season as they host Gilmer County Friday night.
The Devils got off to an 0-3 start before a 39-0 victory over Tyler Consolidated in Week 4.
Last week St. Marys notched win number two of the season, a 42-20 victory over Calhoun County.
St. Marys used a balanced attack to down Calhoun, getting 95 yards rushing from Cole White on 13 carries and solid rushing efforts from David Gray (9-85), Noah Spitzer (17-55) and quarterback K.D. Arnett (17-55).
Key players to watch for Gilmer County will be quarterback Austin Cunningham and receivers Dylan Montgomery and Nate Allison.
Last year St. Marys easily handled Gilmer 41-18.
PARKERSBURG CATHOLIC (4-3) AT VALLEY FAYETTE (5-1)
If the Parkersburg Catholic Crusaders are to get their fifth win of the season they will have to handle a very tough Valley Fayette Greyhound team in Fayette County Friday night.
The Crusaders are coming off of a 44-19 win over South Harrison last week, while Valley Fayette defeated Pendleton County 18-0.
Key players for VF include running backs Cody Winter and Keyshawn Payne and quarterback Tyler Chaffins.
Catholic has been paced all year by the trio of quarterback Daniel Collie, running back Zack Romine and receiver Mitch Davis.
Last year the Crusaders defeated Fayette 28-0 in Parkersburg.